In which groups does endometrial adenocarcinoma occur most often?

Endometrial adenocarcinoma mostly occurs in postmenopausal women, obese people, patients with hypertension or diabetes, people with long-term anovulatory menstrual abnormalities, and people with a family history of inheritance.

1. Postmenopausal women

Postmenopausal women have relatively elevated levels of estrogen and a lack of progesterone. Long-term stimulation of the endometrium by estrogen may lead to hyperplasia and even cancer. Such patients often present with postmenopausal irregular vaginal bleeding and require vaginal ultrasound and diagnostic dilation and curettage for a clear diagnosis. Treatment requires surgical resection, radiotherapy or hormonal therapy according to the stage. Commonly used drugs include medroxyprogesterone acetate tablets, letrozole tablets, etc.

2. Obese people

Aromatase in the adipose tissue of obese people can convert androgens into estrogen, leading to increased estrogen levels in the body. Obesity is also associated with insulin resistance, which may further stimulate endometrial hyperplasia. In addition to weight control, such patients need regular gynecological examinations. In the early stage, the lesions can be removed through hysteroscopic surgery. In the late stage, they need to be combined with chemotherapy drugs such as paclitaxel injection and carboplatin injection.

3. Patients with high blood pressure or diabetes

Hypertension and diabetes may increase the risk of endometrial cancer by affecting vascular endothelial function and hormone metabolism. Such patients often suffer from metabolic syndrome, which manifests as polydipsia, polyuria, dizziness and other symptoms. Treatment needs to be based on the stage of the cancer while controlling the underlying disease. Commonly used drugs include insulin injections, metformin sustained-release tablets, etc.

4. People with long-term anovulatory menstrual abnormalities

The anovulatory state caused by diseases such as polycystic ovary syndrome causes the endometrium to be stimulated by estrogen for a long time without progesterone opposition. Patients often have a history of oligomenorrhea, amenorrhea or irregular bleeding. Treatment needs to correct endocrine disorders. Ethinyl estradiol and cyproterone tablets can be used to regulate the menstrual cycle, and endometrial ablation can be performed if necessary.

5. People with family genetic history

Carriers of genetic diseases such as Lynch syndrome have DNA mismatch repair gene defects and have a significantly increased risk of endometrial cancer. Such patients may have a family history of bowel cancer, ovarian cancer, etc. It is recommended to undergo regular genetic testing and endometrial biopsy. Prophylactic hysterectomy can be considered, and long-term follow-up monitoring is required after surgery.

To prevent endometrial adenocarcinoma, you need to maintain a healthy weight, control blood pressure and blood sugar, exercise regularly, and avoid long-term use of single estrogen preparations. Postmenopausal women should seek medical attention promptly if they experience vaginal bleeding. Those with high-risk factors are recommended to undergo annual gynecological examinations and ultrasound monitoring. Confirmed patients need to follow the doctor's advice and undergo standardized treatment, regularly review tumor markers and imaging examinations after surgery, pay attention to nutritional supplements, and avoid overexertion.