Mudizi

　　Momordica cochinchinensis (Lour.) Spreng. is the mature seed of Momordica cochinchinensis (Lour.) Spreng. Mainly produced in Hubei, Guangxi, Sichuan and other places. Mostly wild, but also cultivated. Harvest mature fruits from September to November, cut them open, dry them in the sun, take out the seeds and dry them. When used, remove the shells and extract the kernels, mash them, or make frosting.

　　[Medical properties] Bitter, slightly sweet, cool. poisonous. Returns to the liver, spleen and stomach meridians.

　　[Efficacy] Attack poison, treat sores, reduce swelling and dissipate knots.

　　【application】

　　1. Sores, swollen sores, scrofula, mastitis, hemorrhoids, psoriasis, and baldness. This product can dissipate stagnation and reduce swelling, attack poisons and treat sores, and has myogenic and analgesic effects, so it can treat the above-mentioned diseases. If you use this product alone, apply it to the affected area with vinegar grind juice or powdered vinegar. To treat carbuncle, swollen and other poisons, it can be stir-fried with Cao Wu, Pinellia ternata, etc. and ground into fine pieces, mixed with water and applied externally, such as Oolong ointment ("Yi Zong Jin Jian"). To treat swelling and pain of hemorrhoids, "Puji Fang" is mixed with Schizonepeta and Nitrile and boiled in equal parts, fumigated and washed. To treat scrofula and phlegm cores, this product can be ground into eggs, steamed and cooked, such as wood turtle paste ("Renzhai Zhizhi Prescription"). If you want to treat bruises, bruises, swelling and pain, you can mix it with cinnamon, cloves, etc., grind it into powder, cook rice porridge with ginger juice, make a paste, and apply it externally, such as wood turtle wrap recipe ("Shengji Zonglu").

　　2. Muscle spasm. This product can also dredge the meridians and treat numbness, pain and paralysis. You can mix frankincense as a powder, clear oil and yellow wax as an ointment, take a little and rub the affected area, and do not stop using extreme heat as a measure, such as Mudizi ointment ("Hundred One Prescriptions").

　　[Usage and Dosage] For external use, grind an appropriate amount into powder and apply it to the affected area with oil or vinegar. Take 0.6~1.2g orally, usually in the form of pills or powder.

　　[Usage Note] Pregnant women and those with physical weakness should not take this product.

　　[Identification and use of medicines] Both Schizophrenia and Nux Vomica are poisonous products. They can reduce swelling and dissipate knots, unblock meridians and relieve pain. They are used to treat sores, carbuncles, swelling and pain, bruises and other injuries. However, Trichosanthes vulgaris is a plant in the family Cucurbitaceae and is good at attacking poisons and treating sores. It is clinically used for malignant sores, scrofula, mastitis, and hemorrhoids. Nux Vomica is a plant in the family Nux vomicaceae, also known as strychnine. It is highly toxic and should be used with caution. It is good at unblocking meridians, reducing swelling and relieving pain. It is clinically used for rheumatism, paralysis, bruises, and other conditions. The pain relief is stronger than Trichosanthes nux.

　　[Abstract from ancient books]

　　1. "Kaibao Materia Medica": "It is mainly used for breaking wounds, removing knots and swelling, malignant sores, promoting muscle growth, relieving low back pain, removing acne, black stems and black galls, breast cancer in women, and anal swelling and pain." ”

　　2. "Compendium of Materia Medica": "Cures malnutrition and lumps, promotes diarrhea in the large intestine, hemorrhoids and scrofula. ”

　　【Modern Research】

　　1. Chemical composition: Contains saponin, agaric acid, amaranth, oleanolic acid, , amino acids, as well as 35.72% oil, 30.59% protein, trehalose, etc.

　　2. Pharmacological effects: Trichosanthes saponins have anti-inflammatory and hypotensive effects, and can inhibit isolated frog hearts and isolated rabbit duodenum.

　　3. Clinical research: It is reported that the use of wood turtle seeds or appropriate combinations to treat various diseases such as psoriasis, psoriasis, baldness, etc., has a satisfactory effect. In recent years, it has also been reported: Grind 1 wood turtle seed and soak it in an appropriate amount of 75% ethanol. After 48 to 72 hours, filter it and add 3g. and 10ml of glycerin, add 75% ethanol to 100ml, apply it to the affected area, and the effect of treating neurodermatitis is obvious (Chinese Journal of Medicine, 1984, 4:11); Grind the seeds of wood turtle (shelled), peppermint, patchouli, and borneol into fine powder in the ratio of 5:5:3:1, and take 0.05g each time. Nasal (inhaled into the nostril on the painful side), about 4 times a day, 62 cases of trigeminal neuralgia were treated, with an effective rate of 91.9% (Journal of Traditional Chinese Medicine, 1994, 1:35); split 3 wood turtle seeds, fry them in sesame oil until black, take the oil and apply it on the ears, and treated more than 60 cases of otitis media with very good results (Journal of Shandong Traditional Chinese Medicine, 1993, 4:50). In addition, it can treat breast hyperplasia, diarrhea in children, anal prolapse, etc.

　　4. Adverse reactions: Both water and ethanol leaching solutions of wood turtle seeds are highly toxic, and their saponins have hemolytic effects. [Pharmaceutical Journal (Japan), 1971, 2:174]. The symptoms of poisoning are: nausea, vomiting, headache, dizziness, abdominal pain, diarrhea, weakness in the limbs, blood in the stool, restlessness, disturbance of consciousness, shock, etc. For mild poisoning, gastric lavage with 1:5000 potassium permanganate solution or 0.5% activated carbon, egg white, enema, magnesium catharsis and other methods can be used to detoxify.

　　[Others] Experiments have shown that the animals died within a few days after the antihypertensive effect occurred when administered through arteries or veins [Chinese Academy of Medical Sciences, 1956 Paper Report, Paper Abstract (Ⅱ)].